Functional Tracing of Brain Circuitry by a Novel Approach

Grant number: DP130104661 | Funding period: 2013 - 2016

Completed

Abstract

A genetically modified virus is taken up by axon terminals (the 'output' part of a nerve cell) and transported by the cell back to the cell body (its 'input' part). Once there, it makes a protein that makes the cell sensitive to blue light. This new tool may be instrumental in answering questions about nerve connections that cannot be answered in other ways.

Related publications (3)

On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat

DGS Farmer, N Pracejus, B Dempsey, A Turner, P Bokiniec, JFR Paton, AE Pickering, J Burguet, P Andrey, AK Goodchild, RM McAllen, S McMullan

2019-07-01

Key points: Spinally-projecting neurons of the rostral ventrolateral medulla (RVLM) determine sympathetic outflow to different ter..

Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia

DGS Farmer, M Dutschmann, JFR Paton, AE Pickering, RM McAllen

2016-12-15

Key points: Cardiac vagal tone is a strong predictor of health, although its central origins are unknown. Respiratory-linked fluct..

Segmental origins of cardiac sympathetic nerve activity in rats

NH Pracejus, DGS Farmer, RM McAllen

2015-01-01

The segmental origins of cardiac sympathetic nerve activity (CSNA) were investigated in 8 urethane-anesthetized, artificially vent..

University of Melbourne Researchers

Robin McAllen